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The CD28 cell surface receptor is a member of the TNF receptor superfamily and plays a critical role in mediating T cell responses. Mice with a targeted deletion of CD28 are characterized by massive CD8 T cell expansion and chronic but mild autoimmune disease. The CD28 ligands IL-2 and CD80/CD86, although unable to induce T cell growth and proliferation alone, synergize with CD3 cross-linking to promote T cell activation. Genomic analysis of the CD28 locus was used to map the structure of the family and to develop a global model of CD28 transcriptional regulation. A highly conserved upstream regulatory element lies between and upstream of the CD28 and CTLA-4 genes and is preferentially expressed in activated lymphocytes. This region contains the TATA element characteristic of housekeeping genes and is required for efficient transcription of CD28 and CTLA-4 in activated T cells. The CD28 coding sequence is located upstream of the conserved regulatory elements and contains a TATA element and other promoter elements reminiscent of the IFN-alpha and IL-2 genes. Both the CD28 and CTLA-4 genes are expressed at the RNA level and are subject to long-range regulation by cis and trans mechanisms. This means that the gene products would not need to be limited to a defined region of the T cell membrane to function.Next Big Thing)
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Get access to a 25-year-old dataset of great earthquakes that the USGS has archived, along with the maps and code that allow you to explore it.
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Jan. 17-20: Big Sur Special Section
The Big Sur Special Section reports on the field
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Nov 26, 2012 – PhraseExpress is an on-the-fly updating toolkit to deliver a seamless update experience to MS. Word, Excel, PowerPoint, and Outlook. We’ve been working on various tools .
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Anstey had stumbled on what is now known as an atmospheric thermostat, a solar-powered ‘vacuum pump’ that takes in sunlight and then lets the rest of the atmosphere out. The same thing happens in Earth’s near-vacuum atmosphere, although the mechanism is
