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we assume that w ~bern(p) and r ~bern(p), where p is the prior distribution of the regression coefficients. this is a conservative assumption, as if more information was available, the prior knowledge would be adapted using it. the gamma distributions are chosen because they are conjugate distributions and conjugate priors are the standard priors adopted in most of existing bayesian analyses [ 14 ]. in this bayesian model, the prior of the regression coefficients are gamma (formula 3) distribution.
cns is the center of the central nervous system, which is the main controller of the body and the most complex organ in human body. however, there are no adequate long-term clinical data on the safety, tolerability, immunogenicity and safety of live-attenuated mumps vaccine, and live-attenuated measles and rubella vaccines during pregnancy or infancy. in addition, the risk of adverse events (aes) and neurodevelopmental outcomes are unknown for any other licensed live-attenuated or nonlive vaccine in routine use. a randomized, double-blind, placebo-controlled trial of mumps (mmr) vaccine use during pregnancy did not find any safety concerns or increased risks of adverse pregnancy outcomes [ 49 ]. similarly, a follow-up of all infants enrolled in the placebo arms showed no differences in neonatal morbidity, infants aged 0 to 3 months were found to have a slightly lower prevalence of hospitalization or antibiotic use.
this research was funded by natural science foundation of tianjin city (17jczdjc33600) and key laboratory of endocrine related diseases of tianjin (17skldxxx01), and key laboratory of endocrine related diseases of ministry of health of tianjin (17skldsy026). authors are grateful to all patients for their participation in the study. we are particularly grateful to zongquan ma, chaofeng yang, lu dong, and yuejiao xia for their technical assistance, and to kai li, xuan zhang and jin yin for proofreading this manuscript.
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