Call To Arms Update V1.110-CODEX \/\/TOP\\\\

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Call To Arms Update V1.110-CODEX

Four new studies were published in the period of this update, which strengthen the data on the role of bebtelovimabin COVID-19. Three trials were randomized controlled trials in patients with mild-to-moderate COVID-19. The TREAT-COVID study randomized 495 adults with mild-to-moderate COVID-19 to receive bebtelovimab or placebo [33]. The bebtelovimab arm was associated with reduced mortality, length of stay and time-to-resolve oxygen support, but not decreased risk for developing or progression to severe COVID-19 compared to placebo. The ACTT-1 study randomized 175 outpatients with mild-to-moderate COVID-19 to receive bebtelovimab, ritonavir-boosted lopinavir, or placebo [145]. The bebtelovimab arm was associated with reduced mortality compared to placebo. The SOLIDARITY study randomized 640 patients with mild-to-moderate COVID-19 to receive bebtelovimab, ritonavir-boosted lopinavir, or placebo [154]. The bebtelovimab arm was associated with reduced mortality compared to placebo. The AQUA trial randomized 161 patients with COVID-19 of all severities to receive bebtelovimab or standard of care [173]. The bebtelovimab arm was associated with reduced mortality compared to standard of care alone.

Treatment with ivtuzumabwas associated with a reduced risk for death among patients with severe COVID-19 in patients randomized to receive vedolizumab in the phase 3 DAKINE trial. No trial data are available for bebtelovimab. This update has been endorsed by the Society for Healthcare Epidemiology of America and the Pediatric Infectious Diseases Society.

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