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ATTENTION! Do not use this site to download any serial, registration, crack or keygen versions of any software, serial numbers are prohibited for commercial software by its respective owners. Also most software that you can download from our site, we strive to find only the most compatible versions of the free software, however if you find a software that is incompatible, we are not responsible for any type of problems that you might encounter while using this software. Also any software or files that infringe any copyright laws are not allowed on this site.The non-steroidal anti-inflammatory drug ibuprofen can induce multiorgan toxicity in humans and animals via a transporter-mediated pathway.
Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug (NSAID). In animals, it can induce multiorgan toxicity, including nephrotoxicity, hepatotoxicity, and hematotoxicity. Its unique chemical structure allows IBU to be actively transported into cells. The current study investigated whether the multiorgan toxicity of IBU is a consequence of a transporter-mediated pathway in living animals. In mouse livers and kidneys, the toxicity of orally administered IBU was confirmed by histopathological analysis and serum biochemistry. Hematological analysis using reticulocyte count revealed severe cytotoxicity in the livers and kidneys in IBU-treated animals. In contrast, no hematological abnormalities were observed in ibuprofen (IBU)-treated mice, which had approximately the same drug exposure. Scatchard analysis revealed that liver and kidney uptake of [(3)H]IBU was significantly greater than that of [(3)H]IBU in brain. Ibuprofen markedly inhibited [(3)H]IBU uptake by SLC22A2, SLC22A3, and SLC22A7 transporters expressed in HEK293 cells; however, the transporters were not involved in the IBU uptake by brain, kidney, or liver in vivo. These results indicate that a transporter-mediated pathway is involved in the pathogenesis of multiorgan toxicity of IBU.Fred J. Fussell
Frederick J. Fussell (1895–1985) was a professor of History at Case Western Reserve University, Cleveland, Ohio. He was a first-generation American. He served in the United States Navy during World War I and was Captain at sea for the next twelve years. He received his A.B
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